用药不当可致男性不育
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<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-ALIGN: left; mso-pagination: widow-orphan" align=left><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt"><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p> </o:p></SPAN></P></TD></TR></TBODY></TABLE>
<P class=MsoNormal style="MARGIN: 0cm 0cm 12pt; LINE-HEIGHT: 150%; TEXT-ALIGN: left; mso-pagination: widow-orphan" align=left><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥">男子不育的原因复杂且是多方面的，用作治疗疾病的某些药物也能导致男性精子障碍，使男性不育。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt"><BR><BR></SPAN><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥"> 药物导致男性不育的机制是：某些药物可直接抑制睾丸内曲细精管的细胞分裂。阻碍正常精子细胞的形成；某些药物则可通过抑制人体的间脑</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt">—</SPAN><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥">垂体系统，间接地通过激素干扰睾丸制造精子的功能。直接抑制睾丸曲细精管细胞分裂的药物如：硝基呋喃、二氯乙酰联胺、噻吩等类，能阻止精原细胞、初级精母细胞的蛋白质合成，即使采用的是常用量，也会对造精功能有抑制作用。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt"><BR><BR></SPAN><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥"> 有关资料介绍，某些羟基化合物结构的药物，如苯丁酸氮芥、环磷酰胺等能抑制造精功能，而且，即使停药也不易恢复正常；许多抗癌药物，不论是单独使用还是联合使用，都可不同程度地影响造精功能，如使用长春新碱，会通过抑制</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt">MRNA</SPAN><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥">（细胞内遗传信息的</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt">“</SPAN><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥">信使</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt">”</SPAN><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥">）的合成和蛋白质的合成而损害造精功能，使睾丸内的精原细胞、初级精母细胞及精子细胞的分裂停滞，失去孕育能力。但是，这种损害与羟基化合物不同，对细胞的损害程度较轻，睾丸间质细胞正常，一旦停止用药，造精功能可恢复正常；用于治疗溃疡病的西咪替丁，可阻碍雄性激素受体的正常活动而使精子产生异常。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt"><BR><BR></SPAN><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥"> 影响垂体功能的药物，如单胺氧化酶抑制剂，可使垂体分泌促进性腺激素减少；大量使用类固醇类激素，如睾丸酮及黄体酮、雄激素等也会间接地抑制造精功能。影响男子造精功能的药物很多，且与药物的组合情况、使用量、使用时间长短等因素密切相关。容易被人们忽视的是，大量使用阿司匹林及维生素</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt">B12</SPAN><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥">、维生素</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt">E</SPAN><SPAN style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt; mso-ascii-font-family: ˎ̥; mso-hansi-font-family: ˎ̥">等，也会抑制造精功能，也应当注意。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 9pt; LINE-HEIGHT: 150%; FONT-FAMILY: ˎ̥; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt"><o:p></o:p></SPAN></P></TD></TR></TBODY></TABLE></DIV>
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